ISO100 is the cleanest, fastest whey in this lineup: a pre-hydrolyzed 100% whey isolate that delivers 25 g of protein for only about 120 calories, with 1 g of fat and 1 g of sugar. Cross-flow micro-filtration strips most of the lactose, fat and cholesterol, and hydrolysis pre-cleaves the protein for rapid absorption — making it the dedicated post-workout pick for people who want the leanest possible macro profile. It's also consistently top-rated for mixability and chocolate flavor. The trade-offs are straightforward and we name them. It's sweetened with sucralose and acesulfame potassium, both artificial sweeteners, so it's out if you want a stevia-only label. It carries a premium price over commodity whey — about $1.06 per serving versus $0.95 for our #1. And while Dymatize states it's Informed Choice certified, this listing doesn't assert an Informed Sport or NSF seal, so we credit the brand's certification as stated and no further. For an athlete who wants a true lean isolate around training and isn't bothered by sucralose, it's the best-in-class choice — just a step behind Gold Standard on overall value.
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Read the complete Protein Powder guide →The strongest protein profile here: 25 g of pre-hydrolyzed 100% whey isolate — the fastest-digesting, leanest form of whey — for only ~120 calories with 1 g fat and 1 g sugar. Cross-flow micro-filtered to strip lactose, fat and cholesterol. As pure a high-quality protein dose as the category offers.
A fully disclosed 100% whey isolate with no proprietary protein blend and no amino-spiking concern — the protein number is clean and verifiable. Held just below a perfect mark only because the formula relies on artificial sweeteners; on protein disclosure itself it's excellent.
Dymatize states ISO100 is Informed Choice certified — a real banned-substance screening program — but this retail listing doesn't assert an Informed Sport or NSF seal, so we credit the brand's certification as stated and no further. Stronger than a flat "None stated," a notch below picks with a seal on the listing itself.
A premium product. At roughly $1.06 per serving across 71 servings, it costs more per gram than commodity whey like Gold Standard (~$0.95). The premium buys a pure hydrolyzed isolate with leaner macros — fair value for what it is, but it loses the pure cost-per-gram contest to the blends.
Consistently top-rated for both — the Gourmet Chocolate flavor is a category favorite and the isolate dissolves cleanly without grit or clumping. As an isolate it mixes thin and smooth in water. A genuine daily-compliance strength.
“25 g of fast-absorbing hydrolyzed 100% whey isolate.”
Stated on the listing and consistent with a hydrolyzed isolate at this serving size. Hydrolysis genuinely pre-cleaves the protein for faster absorption, and the 100% isolate form is fully disclosed with no protein blend — an accurate, verifiable claim.
“Only ~120 calories with 1 g fat and 1 g sugar.”
The lean macro figures are stated on the listing and are exactly what cross-flow micro-filtration of a whey isolate produces. Among the leanest macro profiles in the category — accurate as stated.
“Informed Choice certified.”
Credited as stated by Dymatize — Informed Choice is a legitimate banned-substance screening program. Marked partial only because this specific retail listing does not itself assert the seal, so we report the brand's claim without upgrading it to a listing-level certification.
ISO100's defining strength is its macro profile: 25 g of protein for ~120 calories, with 1 g fat and 1 g sugar, from a pre-hydrolyzed 100% isolate. Nothing else here is both this lean and this fast-digesting. For a dedicated post-workout shake — or for anyone deliberately minimizing calories around their protein — it's the best tool in the ranking. The honest caveat: total daily protein, not digestion speed, is what actually drives results, so the speed edge is a refinement, not a requirement.
Because it's a cross-flow micro-filtered isolate rather than a concentrate, ISO100 has most of its lactose stripped out — meaningfully less than a concentrate like Naked Whey (#6) retains. That makes it one of the gentler whey options for people who get bloating from cheaper concentrate. It still contains milk and soy lecithin, so it's not for a dairy allergy, soy avoidance, or a vegan diet.
At about $1.06 per serving, ISO100 costs more per gram than commodity whey. You're paying for the hydrolyzed-isolate processing, not for more usable protein — Gold Standard (#1) delivers a comparable protein dose for less. The premium is justified if the lean macros and fast digestion matter to your specific use; it's wasted money if you just need everyday protein, where the cheaper blend does the same job.
ISO100 is the cleanest, fastest whey here: a pre-hydrolyzed 100% isolate with about as lean a macro profile as protein gets and a reputation for mixing flawlessly. For an athlete who wants a true lean isolate around training, tolerates isolate better than concentrate, and isn't bothered by artificial sweeteners, it's the best-in-class pick in this lineup. It lands at #2 rather than #1 on value and sweeteners. At ~$1.06 a serving it costs more per gram than Gold Standard (#1), and it relies on sucralose and acesulfame potassium where stevia-sweetened picks don't. Read its certification honestly too: Informed Choice is real and credited as stated, but this listing doesn't assert the seal itself. If you want the leanest, fastest post-workout protein, ISO100 is the answer. If you want the lowest cost per gram, or a stevia-only label, the rest of the ranking has better fits.
Check Dymatize · 25g hydrolyzed whey isolate, ~120 cal · 71 servings on AmazonThe value benchmark — 24 g of quality whey at the lowest cost per serving here (~$0.95). Pick this if everyday affordability beats a pure lean isolate; the blend's slightly higher carbs and fat won't matter.
See it on the list →28 g per scoop from grass-fed whey with no artificial sweeteners — the clean-label isolate. Choose this if you want a lean isolate but specifically want stevia, not sucralose.
See it on the list →Native whey, naturally high in leucine, stevia-sweetened and Informed-certified per the brand. The pick if you want a clean isolate-grade whey with a seal and zero artificial sweeteners.
See it on the list →Meta-analysis of 49 studies (1,863 participants): protein supplementation significantly augmented resistance-training gains in muscle mass and strength, plateauing around 1.6 g/kg/day. The reason a lean, high-quality isolate like ISO100 is judged on whether it helps you reach that target.
Pooling 22 RCTs, supplemental protein during resistance training significantly increased fat-free mass, fiber cross-sectional area and 1-RM strength. Confirms supplemental whey meaningfully enhances the training response — the basis for ISO100's post-workout positioning.
Systematic review concluding protein supplements enhance gains in muscle mass and strength during prolonged resistance training, with weaker effects on aerobic/anaerobic power. An honest read of where a quality isolate clearly helps versus where the evidence is thinner.
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