Dymatize ISO100 Hydrolyzed Whey Protein Isolate Review

Hydrolysis pre-cleaves the whey protein into shorter peptide chains, so it's already partially "pre-digested" before you drink it. In practice that means fast absorption — which is why ISO100 is positioned as a post-workout protein. It's also a 100% whey isolate, cross-flow micro-filtered to strip most of the lactose, fat and cholesterol, giving it very lean macros (1 g fat, 1 g sugar, ~120 calories per 25 g), per the listing. The practical upshot: it's the leanest, fastest-digesting whey in this lineup, on its stated numbers. For everyday protein, that speed edge is nice-to-have rather than essential — total daily protein is what drives results.

Only if you specifically want a pure, lean isolate. At about $1.06 per serving, ISO100 costs more per gram than our #6, Optimum Nutrition Gold Standard (~$0.95/serving), which is a WPI-primary blend. What the premium buys is a 100% hydrolyzed isolate with leaner macros and faster digestion. If you're chasing the leanest possible post-workout shake or you tolerate isolate better than concentrate, it's worth it. If you just want reliable, affordable protein to hit a daily target, Gold Standard does that job for less and the blend's marginally higher carbs and fat won't matter.

Dymatize's own marketing states ISO100 is Informed Choice certified. We could not verify a legible Supplement Facts panel for this listing, so we can't confirm or rule out an Informed Sport or NSF seal directly from the label — we credit the Informed Choice certification as stated by the brand and go no further. Informed Choice is a real, legitimate certification program that screens for banned substances. If you need a seal you can verify directly on the listing, Naked Whey (#5, NSF Certified) and Ascent (#3, Informed-certified per brand) are worth checking too.

Per the listing, yes on both counts. ISO100 is sweetened with sucralose and acesulfame potassium, both artificial sweeteners — if you want to avoid those, look at a stevia-sweetened pick like Transparent Labs (#2) or Ascent (#3). The listing also states it contains milk and soy (from soy lecithin), so it's not suitable if you're avoiding soy, and lists it as gluten free. We could not confirm any of this against a legible Supplement Facts or ingredients photo in this listing's gallery.

It's one of the better whey options for sensitive stomachs, per the listing. As a cross-flow micro-filtered 100% isolate, ISO100 is described as having most of the lactose stripped out — considerably less than a whey concentrate like Naked Whey (#5) retains. That makes it gentler for many people who get bloating from concentrate. It still contains milk per the listing, so it isn't suitable for a true dairy allergy or a vegan diet — for fully dairy-free protein, see the plant picks (Garden of Life SPORT or KOS).

1. [1] Morton 2018 PMID 28698222 — A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Meta-analysis of 49 studies (1,863 participants): protein supplementation significantly augmented resistance-training gains in muscle mass and strength, plateauing around 1.6 g/kg/day. The reason a lean, high-quality isolate like ISO100 is judged on whether it helps you reach that target.
2. [2] Cermak 2012 PMID 23134885 — Protein supplementation augments the adaptive response of skeletal muscle to resistance-type exercise training: a meta-analysis. Pooling 22 RCTs, supplemental protein during resistance training significantly increased fat-free mass, fiber cross-sectional area and 1-RM strength. Confirms supplemental whey meaningfully enhances the training response — the basis for ISO100's post-workout positioning.
3. [3] Pasiakos 2015 PMID 25169440 — The effects of protein supplements on muscle mass, strength, and aerobic and anaerobic power in healthy adults: a systematic review. Systematic review concluding protein supplements enhance gains in muscle mass and strength during prolonged resistance training, with weaker effects on aerobic/anaerobic power. An honest read of where a quality isolate clearly helps versus where the evidence is thinner.