“800 mcg folic acid provides NTD protection”
800 mcg sits within the USPSTF-recommended 400–800 mcg folic acid range (PMID 28097362); the Cochrane review (PMID 26662928) confirms folic acid's protective effect across this dose window.
NOW's folic acid tablet clears the prenatal folate target with room to spare — 800 mcg of folic acid, the same NTD-proven form as our top pick, plus 25 mcg of B-12 to support homocysteine metabolism. At roughly $8 for 250 tablets it is the cheapest way here to exceed the 400 mcg minimum. It loses a hair to Nature Made only because it carries GMP self-attestation rather than an independent USP seal, but the underlying substance and evidence are identical. If you want margin above the minimum dose and a token of B-12, this is the value play.
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Read the complete Folate guide →Uses folic acid, the exact form validated in the MRC and Czeizel trials and recommended by the USPSTF.
Standard synthetic folic acid, well-absorbed; the 25 mcg B-12 supports the same one-carbon metabolism pathway.
800 mcg is at the top of the 400–800 mcg DFE prenatal range — fine and well within safe limits, though more than the 400 mcg minimum most need.
GMP Quality Assured and Non-GMO, but self-attested; no independent USP or NSF seal like the top pick.
Roughly $0.03 per tablet — the lowest cost-per-dose on the entire list.
“800 mcg folic acid provides NTD protection”
800 mcg sits within the USPSTF-recommended 400–800 mcg folic acid range (PMID 28097362); the Cochrane review (PMID 26662928) confirms folic acid's protective effect across this dose window.
“Adding B-12 improves homocysteine metabolism”
Folate and B-12 jointly lower homocysteine, but a 25 mcg B-12 dose is modest and the clinical benefit of homocysteine-lowering for pregnancy outcomes is not firmly established.
Doubling the dose to 800 mcg stays well under the 1,000 mcg tolerable upper intake for folic acid and gives a comfortable margin, but there is no evidence 800 mcg prevents more NTDs than 400 mcg for the average woman.
Including B-12 addresses the second nutrient in the homocysteine pathway and can help vegetarians, but 25 mcg is a supportive touch rather than a therapeutic dose.
If cost is the deciding factor and you still want the evidence-based form, this is the pick. You get the same folic acid used in the NTD trials, a generous dose, and B-12, for the least money. The only reason it sits at #2 is the absence of an independent testing seal — a real but modest gap versus Nature Made.
Check NOW Foods on AmazonRecommends 400–800 mcg folic acid daily for those who could become pregnant.
Folate supplementation had a protective effect against neural-tube defects.