Top 9 Best 5-HTP Supplements (2026)
We make this one. Our own Super Achiever formula — held to the exact same 50/50 criteria as every pick below, and we put it up top so you see it first. Full transparency: it's ours.
- #0200 mg
Super Achiever 5-HTP (200 mg · Griffonia)
Super Achiever Club · ships direct from our storeOur in-house 5-HTP — 200 mg from Griffonia simplicifolia seed, the direct serotonin precursor for mood, appetite and sleep support. Pinned here because it's ours, held to the same 50/50 criteria.
- Form
- 5-HTP from Griffonia simplicifolia seed extract
- Dose
- 200 mg per 2-capsule daily serving
- Size
- 60 capsules · 2 per day
- Best for
- Mood, appetite, easier sleep
Pros- 200 mg Griffonia-sourced 5-HTP — the studied serotonin precursor
- Includes calcium; single-purpose formula, no proprietary clutter
- USA-made, gluten-free, sugar-free
- Ships direct from us — no marketplace middleman
Honest trade-offs- Must NOT be combined with SSRIs/SNRIs/MAOIs/triptans — serotonin-syndrome risk; ask a clinician first
- 200 mg/day is an experienced-user dose, not a 100 mg beginner step
- Gelatin capsule — not vegan; not enteric-coated
Our take — If 200 mg is the 5-HTP dose you want, this is our own — straight Griffonia-seed 5-HTP at a fair price. It's an experienced-user dose in a gelatin cap, and because 5-HTP raises serotonin it's off-limits alongside antidepressants — we flag that loudly rather than bury it.
9 picks — ranked by our 50/50 methodology
- #1Best overall
NOW Supplements 5-HTP 100 mg
NOW Foods · 100 mg 5-HTP from Griffonia simplicifolia · 120 veg capsules9.4/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%9.0
- Source & purity (Griffonia)25%9.5
- Third-party testing20%8.0
- Value per day15%10.0
- Real-world mood/sleep response10%8.5
The no-frills default: a clean 100 mg Griffonia-sourced dose from a high-volume GMP brand at one of the lowest costs per capsule on the list. The right first bottle for most people.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- Griffonia simplicifolia seed extract
- Cofactors
- None (single-ingredient)
- Coating
- Not enteric-coated
- Count
- 120 veg capsules
- Testing
- NOW in-house QC · GMP facility
Pros- Low price for 120 servings — among the best cost-per-capsule here
- Simple, single-ingredient 100 mg dose — the standard starting strength
- Vegan capsule, Griffonia-sourced, made without gluten/soy, widely available
Cons- No B6/C cofactors included
- Not enteric-coated — some users report mild GI upset on an empty stomach
- House/GMP testing only, not independently third-party certified
Our take — If you just want to try 5-HTP without overthinking it, this is the bottle. It's a clean 100 mg Griffonia dose from a brand that ships at huge volume with consistent GMP quality, at a price that makes a multi-month trial cheap. You give up the cofactors and any enteric coating, and the testing is in-house rather than independently certified — but for a first, standard-strength 5-HTP, NOW is the sensible default. Start at one capsule with food.
- #2Best with cofactors
Doctor's Best 5-HTP Enhanced with Vitamins B6 & C
Doctor's Best · 100 mg 5-HTP + vitamin B6 & C · 120 veg capsules9.1/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%9.5
- Source & purity (Griffonia)25%9.0
- Third-party testing20%7.5
- Value per day15%10.0
- Real-world mood/sleep response10%8.5
Pairs the standard 100 mg dose with vitamin B6 and C — the cofactors involved in converting 5-HTP to serotonin — at a value price. The most complete cheap pick.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- Griffonia simplicifolia seed extract
- Cofactors
- Vitamin B6 + vitamin C
- Coating
- Not enteric-coated
- Count
- 120 veg capsules
- Testing
- House/GMP testing
Pros- Adds B6 + C — the cofactors in the 5-HTP-to-serotonin conversion pathway
- Excellent value: 120 capsules at one of the lowest prices on the list
- Vegan, Non-GMO, gluten-free and soy-free
Cons- Not enteric-coated
- Cofactor doses are modest (supportive, not therapeutic)
- House/GMP testing only, not independently third-party certified
Our take — This is the pick when you want the conversion pathway fully fed without paying more for it. The 100 mg dose is standard, but adding vitamin B6 and C — the cofactors your body uses to turn 5-HTP into serotonin — is a sensible, low-cost upgrade over plain 5-HTP, and Doctor's Best does it at a price that undercuts most single-ingredient bottles. It isn't enteric-coated and the testing is in-house, which is why it sits just behind NOW. For most people choosing between the two, the cofactors make this the slightly smarter buy.
- #3Best clean label
Pure Encapsulations 5-HTP 100 mg
Pure Encapsulations · 100 mg 5-HTP, hypoallergenic · 60 capsules8.8/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%8.5
- Source & purity (Griffonia)25%9.5
- Third-party testing20%8.0
- Value per day15%6.0
- Real-world mood/sleep response10%8.5
The premium clean-label option: a practitioner-channel brand with a minimal hypoallergenic excipient list — basically 5-HTP and cellulose — for sensitive users.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- Griffonia simplicifolia seed extract
- Cofactors
- None (hypoallergenic single-ingredient)
- Coating
- Not enteric-coated
- Count
- 60 capsules
- Testing
- House QC · practitioner-grade brand
Pros- Hypoallergenic, very short ingredient list (5-HTP + cellulose)
- Trusted practitioner-grade brand with a reputation for clean formulation
- Gluten-free and Non-GMO
Cons- Higher cost per capsule than the value picks
- Only 60 count per bottle
- No cofactors and not enteric-coated
Our take — Pure Encapsulations is what you buy when excipients matter to you — sensitive stomachs, multiple intolerances, or just a preference for the shortest possible ingredient list. It's essentially 5-HTP and cellulose, from a brand built around hypoallergenic practitioner-channel formulation. You pay more per capsule and get fewer of them, and there are no cofactors or enteric coating, so it's not the value play. But for a clean-label buyer, it's the most reassuring bottle on the list.
- #4Best budget
Natrol 5-HTP 100 mg Time Release
Natrol · 100 mg 5-HTP, time-release tablet · 90 tablets8.5/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%8.0
- Source & purity (Griffonia)25%8.0
- Third-party testing20%7.0
- Value per day15%10.0
- Real-world mood/sleep response10%8.5
The best-selling mood/sleep pick whose time-release tablet meters the 100 mg out gradually rather than all at once — at the lowest entry price on the list.
- Dose
- 100 mg 5-HTP (1 tablet)
- Source
- 5-HTP, controlled time-release tablet
- Cofactors
- None
- Coating
- Time-release (not enteric-coated)
- Count
- 90 time-release tablets
- Testing
- House/GMP testing · allergen-friendly
Pros- Time-release delivery meters the dose out gradually
- Strong value — 90 tablets at the lowest price on the list
- Best-known US 5-HTP brand; free of major allergens
Cons- Tablet, not capsule — uses binders to hold the time-release matrix
- Time-release is NOT the same as enteric coating (still releases in the stomach)
- No cofactors; house/GMP testing only
Our take — Natrol is the cheapest way into 5-HTP, and the time-release tablet is a genuine point of difference — it spreads the 100 mg out instead of delivering it in one hit, which some people find gentler. Just be clear on what time-release is and isn't: it slows the release, but it does not bypass the stomach the way Solaray's enteric coating is designed to. It's a tablet with binders, single-ingredient, house-tested. For a low-commitment first try where price is the deciding factor, it's the value budget pick.
- #5Best enteric-coated
Solaray 5-HTP with Vitamin C & B-6 (Enteric Coated)
Solaray · 100 mg 5-HTP, enteric-coated + B6 & C · 60 veg capsules8.3/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%9.5
- Source & purity (Griffonia)25%8.5
- Third-party testing20%6.5
- Value per day15%7.0
- Real-world mood/sleep response10%8.5
The only genuinely enteric-coated pick: the coating is designed to bypass stomach acid so the 5-HTP releases lower in the GI tract — and it bundles 200 mg vitamin C and 25 mg B6.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- Griffonia simplicifolia seed extract
- Cofactors
- 200 mg vitamin C + 25 mg vitamin B6
- Coating
- Enteric-coated VegCaps (the only one here)
- Count
- 60 enteric-coated veg capsules
- Testing
- Brand 'lab verified' (not independent certification)
Pros- Genuinely enteric-coated — designed to reduce stomach exposure and nausea
- Includes 200 mg vitamin C and 25 mg B6 as conversion cofactors
- Griffonia-sourced, with a 60-day satisfaction guarantee
Cons- Only 60 count per bottle
- Enteric coatings can blunt or slow absorption for some users
- 'Lab verified' is a brand claim, not an independent third-party certification
Our take — If 5-HTP upsets your stomach — the most common complaint with it — Solaray is the targeted answer: it's the one product here that's actually enteric-coated, designed to carry the dose past stomach acid and release it lower down, and it throws in the B6 and C cofactors too. The trade-offs are a smaller 60-count bottle and the fact that enteric coatings can slow or blunt absorption for some people. Note also that Solaray's 'lab verified' is its own claim, not an independent certification. For the nausea-prone buyer, though, it's the most thoughtfully built bottle on the list.
- #6Best third-party tested
Thorne 5-HTP (with Vitamin B6)
Thorne · 100 mg 5-HTP + vitamin B6, third-party certified · 90 capsules8.1/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%8.5
- Source & purity (Griffonia)25%8.5
- Third-party testing20%10.0
- Value per day15%6.5
- Real-world mood/sleep response10%8.0
The testing-forward pick: Thorne is known for third-party certification and is used in pro-sports and clinical settings, with B6 included as a cofactor.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- 5-HTP with vitamin B6 cofactor
- Cofactors
- Vitamin B6
- Coating
- Not enteric-coated
- Count
- 90 capsules
- Testing
- Third-party certified (the standout here)
Pros- Third-party certified — the strongest testing pedigree on the list
- Includes the vitamin B6 cofactor
- Free of gluten, dairy and soy; used in pro-sports/clinical settings
Cons- Pricier per capsule than the mass-market value bottles
- Not enteric-coated
- Single 100 mg strength only
Our take — Thorne is the pick when independent testing is your priority. It's the one bottle here whose quality is backed by genuine third-party certification rather than a brand's own QC, which is why athletes subject to drug testing and clinicians reach for it — and it includes the B6 cofactor. You pay more per capsule than the value picks and it isn't enteric-coated, so it's not the cheapest or the gentlest. But if 'I want to be sure the label is true' is what you care about most, Thorne earns its place.
- #7Best high-dose value
Nutricost 5-HTP 200 mg
Nutricost · 200 mg 5-HTP, batch-tested · 120 veg capsules7.8/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%7.5
- Source & purity (Griffonia)25%8.5
- Third-party testing20%8.5
- Value per day15%9.5
- Real-world mood/sleep response10%6.5
The higher-dose value pick: a full 200 mg per capsule for people who already tolerate 5-HTP and want fewer pills per day — batch-tested by ISO-accredited labs.
- Dose
- 200 mg 5-HTP (1 capsule)
- Source
- Griffonia-sourced 5-HTP
- Cofactors
- None
- Coating
- Not enteric-coated
- Count
- 120 veg capsules
- Testing
- ISO-accredited batch testing · GMP/FDA-registered facility
Pros- High 200 mg dose in a single capsule — fewer pills per day
- 120 capsules at a very low cost per 100 mg-equivalent
- Vegetarian, Non-GMO, and batch-tested by ISO-accredited labs
Cons- 200 mg is a high starting dose — not for beginners
- No cofactors
- Not enteric-coated
Our take — Nutricost is the value choice for people who already know they tolerate 5-HTP and want a 200 mg dose without taking two capsules. On a cost-per-100 mg basis it's the cheapest serious option here, and unlike most mass-market brands it batch-tests through ISO-accredited labs. The catch is in the badge: 200 mg is an experienced-user dose, not a place to start. If you're new to 5-HTP, begin with a 100 mg product and graduate to this only if you need more. For the right buyer, it's excellent value.
- #8Best high-dose time-release
Natrol 5-HTP 200 mg Maximum Strength Time Release
Natrol · 200 mg 5-HTP, time-release tablet · 30 tablets7.5/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%7.5
- Source & purity (Griffonia)25%7.5
- Third-party testing20%7.0
- Value per day15%7.0
- Real-world mood/sleep response10%7.5
A 200 mg dose delivered through Natrol's controlled time-release tablet (releases over roughly 10 hours), positioned for daytime mood and appetite support.
- Dose
- 200 mg 5-HTP (1 tablet)
- Source
- 5-HTP, controlled time-release tablet
- Cofactors
- None
- Coating
- Time-release (~10 hours; not enteric-coated)
- Count
- 30 time-release tablets
- Testing
- House/GMP testing · allergen-friendly
Pros- High 200 mg dose with time-release metering over ~10 hours
- One-tablet-daily convenience
- Allergen-friendly and vegetarian
Cons- Only 30 tablets per bottle — short runway
- 200 mg is a high dose; start lower if you're new to 5-HTP
- Tablet binders; time-release is not enteric coating
Our take — This is the 200 mg version of Natrol's time-release tablet — the same gradual-release idea at double the dose, aimed at people who want a high, all-day 5-HTP level from a single daily tablet. The time-release metering is the appeal; the 30-count bottle and the fact that 200 mg is an experienced-user dose are the limits. As with the 100 mg version, time-release slows the release but doesn't bypass the stomach. A fine pick if you specifically want high-dose, once-daily, time-released 5-HTP — otherwise the 100 mg picks are the safer start.
- #9Best legacy-brand capsule
Jarrow Formulas 5-HTP 100 mg
Jarrow Formulas · 100 mg 5-HTP, HPLC-verified · 60 veg capsules7.3/10SAC Product Score™SAC Product Score™ — how it breaks down- Dose & form (enteric / cofactors)30%8.0
- Source & purity (Griffonia)25%9.0
- Third-party testing20%7.5
- Value per day15%7.0
- Real-world mood/sleep response10%8.0
A long-standing Griffonia-sourced 100 mg capsule from a respected legacy brand, with HPLC-verified purity noted on the label.
- Dose
- 100 mg 5-HTP (1 capsule)
- Source
- Griffonia simplicifolia seeds (HPLC purity-assured)
- Cofactors
- None
- Coating
- Not enteric-coated
- Count
- 60 veg capsules
- Testing
- HPLC purity verification · house QC
Pros- HPLC purity verification noted on the label
- Reputable legacy supplement brand
- Vegan, Non-GMO and allergen-friendly
Cons- Only 60 count per bottle
- No cofactors
- Not enteric-coated
Our take — Jarrow is a perfectly good, clean 100 mg Griffonia capsule from a legacy brand, and its HPLC purity callout is a nice touch of transparency. It lands at #9 not because anything is wrong with it but because it's out-competed on its own terms: NOW and Doctor's Best give you 120 capsules for similar or less money, Pure Encapsulations beats it on clean-label, and Thorne beats it on testing. If it's the one in front of you at a good price, it's a solid single-ingredient buy — just a generalist in a list where most picks have a sharper angle.
▸ Affiliate disclosure: every Amazon link uses our Associates tag (superachieverclub-20). We earn a small commission at no cost to you; it funds independent reviews. We never accept payment to change a ranking.
5-HTP (5-hydroxytryptophan) is the supplement people take when they want to nudge serotonin directly. It is the immediate precursor your body converts — in a single enzymatic step — into serotonin (5-HT), which is why it shows up in three different shopping carts: people chasing mood and stress support, people trying to curb appetite and late-night carb cravings, and people looking for easier sleep on the back of serotonin's role as the raw material for melatonin. Almost every clean 5-HTP on the market is sourced from the same plant — the seed of the West African shrub Griffonia simplicifolia — so the products don't really differ on what's inside. They differ on dose, delivery, cofactors, and how well they're tested. That makes 5-HTP an unusually checkable category. The decisions are concrete: 100 mg (the standard starting dose) versus 200 mg (an experienced-user dose, not a beginner one); plain capsules versus a genuinely enteric-coated capsule designed to bypass stomach acid (only one product here, Solaray, actually is) versus a time-release tablet that meters the dose out gradually (Natrol — which is not the same as enteric coating); 5-HTP alone versus 5-HTP bundled with the vitamin B6 and C cofactors involved in converting it to serotonin; and house/GMP testing versus genuine third-party certification (Thorne is the standout). We bought and sorted nine real, verified single-ingredient 5-HTP products and ranked them on exactly those axes. One safety point belongs at the very top, not buried at the bottom. 5-HTP raises serotonin, so it must NOT be combined with antidepressants (SSRIs or SNRIs), MAOIs, triptans, tramadol, or other serotonergic drugs — the combination can cause serotonin syndrome, a serious and occasionally life-threatening reaction. If you take an antidepressant or have a medical condition, talk to your doctor before taking 5-HTP at all. And be honest about the evidence while you're here: the human trials behind 5-HTP are real but mostly small and old. The best mood data (Shaw 2002, a Cochrane review) found a signal of benefit but flagged that almost none of the studies were high-quality; the appetite/weight data (Cangiano 1992/1998) is more consistent but came from small obese-subject studies at high doses. Treat 5-HTP as a reasonable, low-cost experiment with a meaningful safety caveat — not a proven drug.
Want the no-drama default — a clean 100 mg Griffonia-sourced dose from a high-volume GMP brand at a low cost per capsule: NOW Supplements 5-HTP 100 mg (#1). Want the cofactors built in so the conversion-to-serotonin pathway is fully fed: Doctor's Best 5-HTP with B6 & C (#2) adds them at a value price, or Solaray (#5) does it inside a genuinely enteric-coated capsule if stomach upset is your concern. Want the cleanest, most hypoallergenic label: Pure Encapsulations (#3). Want independent third-party certification above all: Thorne (#6) is the testing-forward pick. Cheapest entry point and a gentler time-release feel: Natrol 100 mg Time Release (#4). Already tolerate 5-HTP and want a 200 mg dose with fewer pills: Nutricost 200 mg (#7) or Natrol 200 mg Time Release (#8) — but 200 mg is not where beginners should start. Whatever you pick: start at 100 mg, take it with food, and do not combine it with antidepressants or other serotonergic drugs without a doctor's sign-off.
How we ranked these nine
5-HTP is close to a commodity — single-ingredient, almost always from Griffonia simplicifolia seed — so we ranked on the things that actually vary between bottles rather than on hype. Dose and form carries the most weight because it's the decision that changes the experience: the right strength for the buyer (100 mg to start, 200 mg only for experienced users), whether the product is genuinely enteric-coated to reduce stomach exposure, and whether it bundles the B6/C cofactors involved in converting 5-HTP to serotonin. Source and purity comes next — every clean pick is Griffonia-sourced, and we gave credit for explicit purity verification (HPLC) and clearly-documented extraction. Third-party testing is the trust filter: independent certification (Thorne) beats house/GMP testing, and batch-testing by accredited labs (Nutricost) sits in between. Value per day is the tiebreaker — cost per serving at the labeled dose. Real-world mood/sleep response — tolerability, GI comfort on an empty stomach, and how consistently users report a felt effect — settles the rest. We did NOT reward marketing 'lab verified' language that isn't an independent certification, and we did not invent any test results: where a brand only does in-house QC, we say so.
- Dose & form (enteric / cofactors)30%
Is the strength right for the buyer — 100 mg as a starting dose, 200 mg as an experienced-user option? Is it genuinely enteric-coated to bypass stomach acid (only Solaray here), or time-released (Natrol — useful but not the same thing)? Does it bundle the vitamin B6 (and C) cofactors that the body uses to convert 5-HTP into serotonin? Plain 100 mg is fine; the form tweaks and cofactors earn the extra points.
- Source & purity (Griffonia)25%
All clean 5-HTP is extracted from Griffonia simplicifolia seed — we required that and gave credit for explicit purity verification. Jarrow's HPLC purity callout and Nutricost's ISO-accredited batch testing score here; a clearly-documented Griffonia source with vegan/Non-GMO status is the baseline. Vague sourcing scores lower.
- Third-party testing20%
The trust filter. Independent third-party certification (Thorne) is the gold standard and scores highest; batch-testing by ISO-accredited labs (Nutricost) earns solid credit; house/GMP testing only is the floor. A brand's own 'lab verified' marketing claim is NOT an independent certification and we scored it as house testing.
- Value per day15%
Cost per serving at the labeled dose. A 120-count bottle at a low price (NOW, Doctor's Best) beats a 60-count premium bottle on pure value; the 200 mg picks are judged on cost per 100 mg-equivalent so the higher strength doesn't artificially flatter them. Tiebreaker within a tier, not a reason to buy a worse-tested product.
- Real-world mood/sleep response10%
Tolerability and the felt experience: GI comfort (5-HTP can cause mild nausea on an empty stomach, which is what enteric coating and time-release try to soften), how consistently users report a mood/appetite/sleep effect, and how easy the format makes daily consistency. Modest by design — the evidence base is real but small, so we don't over-index on subjective response.
The bottom line
5-HTP is one of the simpler supplement categories to shop, because the product is almost always the same single ingredient from the same plant. That means the decision comes down to dose, delivery, cofactors, and testing — and the picks here map cleanly onto those. For most people, NOW Supplements 5-HTP 100 mg (#1) is the right default: a clean 100 mg Griffonia dose, high-volume GMP quality, low cost per capsule, nothing to overthink. If you want the conversion cofactors built in, Doctor's Best (#2) adds B6 and C for the same money, and is arguably the smarter value buy. If 5-HTP tends to upset your stomach, Solaray (#5) is the only genuinely enteric-coated option and bundles the cofactors too. Want the cleanest possible label: Pure Encapsulations (#3). Want independent third-party certification above all else: Thorne (#6). Cheapest entry point: Natrol 100 mg Time Release (#4). And if you already tolerate 5-HTP and want a 200 mg dose, Nutricost (#7) is the value high-dose pick and Natrol 200 mg (#8) the time-release one — but neither is where a beginner should start.
Two rules close it out, and the first is non-negotiable. Do not combine 5-HTP with antidepressants (SSRIs or SNRIs), MAOIs, triptans, tramadol, or other serotonergic drugs — the combination can cause serotonin syndrome, which is serious and occasionally life-threatening. If you take any of those, or have a medical condition, get a clinician's sign-off before taking 5-HTP at all. Second, set expectations honestly: the human evidence for 5-HTP is real but modest. The mood data (Shaw 2002, a Cochrane review) found a signal of benefit but flagged that almost none of the studies were high-quality; the appetite and weight data (Cangiano 1992/1998) is more consistent but came from small studies in obese subjects at high doses. Start at 100 mg, take it with food to reduce nausea, give it a few weeks, and treat it as a low-cost, reasonably-evidenced experiment with a meaningful safety caveat — not a guaranteed fix.
Every claim ranked above traces back to one of these
Peer-reviewed studies, meta-analyses, and clinical trials behind the picks. Click any citation to read the abstract on PubMed.
- [1]Shaw 2002 (Cochrane)
Tryptophan and 5-hydroxytryptophan for depression
Systematic review of 1966-2000 literature: of 108 studies on tryptophan/5-HTP for depression, only 2 (64 patients total) met the quality bar. Pooled, they showed 5-HTP/tryptophan was better than placebo at relieving depression — but the authors stressed the evidence was insufficient and called for higher-quality trials. The honest anchor for 5-HTP's mood claim: a real signal of benefit on a thin, under-powered evidence base.
- [2]Cangiano 1992
Eating behavior and adherence to dietary prescriptions in obese adult subjects treated with 5-hydroxytryptophan
Double-blind RCT in 20 obese subjects, 5-HTP 900 mg/day vs placebo over two 6-week periods. The 5-HTP group showed significant weight loss, reduced carbohydrate intake, and consistent early satiety, with good tolerance. A small but frequently-cited trial behind 5-HTP's appetite/weight positioning — note the high dose used.
- [3]Cangiano 1998
Effects of oral 5-hydroxy-tryptophan on energy intake and macronutrient selection in non-insulin dependent diabetic patients
In overweight non-insulin-dependent diabetic patients, oral 5-HTP significantly decreased energy intake (mainly from reduced carbohydrate and fat) and produced weight loss over the study period. Reinforces the appetite/satiety mechanism seen in the 1992 trial, in a second small clinical population.
- [4]Ceci 1989
The effects of oral 5-hydroxytryptophan administration on feeding behavior in obese adult female subjects
Oral 5-HTP administration to obese adult women reduced food intake and promoted early satiety versus placebo, without dietary restriction. One of the earliest controlled demonstrations of 5-HTP's effect on feeding behavior, underpinning the appetite-control use case.
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